• Three gases, perfluoromethane, perfluoroethane, and perfluoropropane (CF4, C2F6, and C, F8, respectively) were studied for their possible value as intravitreal tamponades in retinal surgery. The gases expand and have intraocular longevities that increase with the length of the carbon chain. A 0.4-cc injection of CF, remained in the eye six days, twice as long as an equivalent amount of air; C2F6 remained 16 days, more than four times as long as air; and C3F8 remained 28 days, nine times as long as air and four times as long as sulfur hexafluoride.
Harvey Lincoff, Jonathan Mardirossian, Andrew Lincoff, Peter Liggett, Takeo Iwamoto, Frederick Jakobiec. Intravitreal Longevity of Three Perfluorocarbon Gases. Arch Ophthalmol. 1980;98(9):1610–1611. doi:10.1001/archopht.1980.01020040462012