• Sixty-eight intraocular lenses were implanted in cats to compare the efficacy of a new polyvinyl alcohol coating in protecting the corneal endothelium from lens-cell contact damage. The mean endothelial density after implantation of the coated lens was significantly higher than the cell density in those eyes receiving the uncoated lens. We saw no clinical signs of unusual inflammation; whole-eye histopathologic study disclosed no signs of inflammation or toxicity related to the coating. Ten coated lenses were placed in balanced salt solution or perfused with balanced salt solution at 0.5 mL/min. The coating remained intact for 60 minutes, affording corneal endothelial protection for this period. In a rabbit anterior chamber toxicity study, using balanced salt solution as a control, no differences in reaction in the anterior chamber or intraocular pressure were noted.
Randall J. Olson, Harry Kolodner, Keith S. Morgan, Humberto Escapini, David Sevel, Herbert E. Kaufman. Polyvinyl Alcohol as a Protective Coating on Intraocular Lenses. Arch Ophthalmol. 1980;98(10):1840–1842. doi:10.1001/archopht.1980.01020040692019