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November 1980

Clinicopathologic Study of Blood-Retinal Barrier in Experimental Diabetes Mellitus

Author Affiliations

From the Georgiana Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology, University of Illinois Eye and Ear Infirmary (Drs Tso and Cunha-Vaz and Ms Shih); and the Department of Anatomy, Abraham Lincoln School of Medicine (Mr Jones), Chicago.

Arch Ophthalmol. 1980;98(11):2032-2040. doi:10.1001/archopht.1980.01020040884020

• Rats with experimental diabetes (induced by streptozocin [Streptozotocin]) were studied by vitreous fluorophotometry and horseradish peroxidase tracer technique. Vitreous fluorescein sodium concentration notably increased four to eight days after a single dose of streptozocin. No leakage from the retinal vasculature could be demonstrated by the horseradish peroxidase tracer study, but three types of retinal pigment epithelial (RPE) lesions were observed. The RPE lesions seemed to be partially responsible for the increase of vitreous fluorescein concentration.

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