—Dr Kottow has misdirected the emphasis of my clinical study on iris neovascular tufts from the observable pupillary lesions to a nonspecific angiogram finding he calls "tuft-like" dye leakage. He fails to relate this peripupillary leakage to iris tufts. While I defer to Dr Kottow's expertise on the incidence of iris "circumscribed leakage spots" in diverse ophthalmic conditions, I do not believe that glomerular microcapillary outgrowths (tufts) occur in these same conditions. Tufts are specific to certain patient groups.The neovascular coils I have described always cause both an early and late persistent focal smokestack extravasation of dye that is profuse. In eyes with tufts, the skip zones on the pupillary border between tufts either do not leak or they fluoresce diffuseMinor iris leakage may occur in some normal persons. However, the study quoted by Dr Kottow never found profuse fluorescein leakage in healthy eyes. Although some
Mason G. Iris Neovascular Tufts-Reply. Arch Ophthalmol. 1980;98(11):2084. doi:10.1001/archopht.1980.01020040936036
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