• Regimens of once-a-day or twice-aday 0.25% timolol ophthalmic solution were compared for efficacy and tolerability in a four-week study of 41 patients with chronic open-angle glaucoma and elevated, untreated intraocular pressure. Significant reductions in IOP relative to untreated baseline values were achieved within a range of 18% to 25%. No significant between-group differences were noted, although the twice-a-day group had somewhat lower IOPs at each evaluation point and the once-a-day group had somewhat fewer subjective symptoms of local irritation. A statistically significant decrease from baseline in mean pulse rate was noted in the twice-a-day treatment group after two weeks; no clinically significant or serious adverse reactions occurred in any patient. Both once-daily and twice-daily administrations of 0.25% timolol ophthalmic solution were found to be effective and well tolerated in the population studied.
Soll DB. Evaluation of Timolol in Chronic Open-Angle Glaucoma: Once a Day vs Twice a Day. Arch Ophthalmol. 1980;98(12):2178–2181. doi:10.1001/archopht.1980.01020041030004
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