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January 1981

Endothelial Mosaic in Fuchs' Dystrophy: A Qualitative Evaluation With the Specular Microscope

Author Affiliations

From the Department of Ophthalmology, Massachusetts Lions Eye Research Laboratory, Boston University School of Medicine (Drs Laing and Leibowitz and Ms Oak) and the Trygve Gundersen Eye Clinic, University Hospital (Drs Leibowitz, Chang, Berrospi, and Theodore), Boston.

Arch Ophthalmol. 1981;99(1):80-83. doi:10.1001/archopht.1981.03930010082007

• The progressive morphological changes of cornea guttata in Fuchs' endothelial dystrophy have been characterized by clinical specular photomicroscopy. Five specific stages in the development of excrescences can be discerned using this in vivo technique. Several stages can be observed in the same cornea at a given time, although in most cases the majority of guttate changes seemed to have progressed to the same stage of development. All five stages of cornea guttata discerned in this study can occur in a cornea clinically free of edema. Two types of cornea guttata can be identified in vivo. One has a smooth, regular posterior surface, whereas the posterior contour of the second is irregular.