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April 1981

Medroxyprogesterone on Corneal Ulceration Its Effects After Alkali Burns on Rabbits

Author Affiliations

From the Department of Cornea Research, Eye Research Institute of Retina Foundation (Drs Foster and Dohlman and Ms Rose) and the Department of Ophthalmology, Harvard Medical School (Drs Foster and Dohlman), Boston; the Division of Ophthalmology, Case Western Reserve University (Dr Lass), Cleveland, and the St Louis Park Medical Center (Dr Campbell), Minneapolis.

Arch Ophthalmol. 1981;99(4):673-676. doi:10.1001/archopht.1981.03930010673014

• The effect of medroxyprogesterone acetate treatment in preventing or retarding corneal ulceration after alkali burns was studied in rabbits in an attempt to correlate dose and response. The eyes were treated for 21 days with a 0.01% or 1% suspension administered topically four times a day or medroxyprogesterone acetate, 4 mg or 30 mg, given subconjunctivally on alternate days. None of these regimens was noticeably effective, although at times there was a trend toward retarding ulceration. Thus, it was not possible to confirm earlier reports of substantial efficacy of medroxyprogesterone. Corneal stroma with epithelial defects and/or ulcers persistently showed infiltration with neutrophils in the superficial stroma within the epithelial defect, implicating the tears as the source of the inflammatory cells.

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