—The major question raised by Sidrys is one that interests us and others. Why does epithelium not migrate into the anterior chamber through a purposeful wound (filtering procedure) and yet tend to grow relentlessly over the internal ocular structures in cases of epithelial ingrowth? Most cases of epithelial ingrowth occur after a complicated procedure with focal trauma to the corneal endothelium. Research using an organ culture model has demonstrated that epithelium is contact inhibited by normal endothelium.1,2 In our case report with the specular microscope, we verified an endothelial cell population of 600/sq mm whose cells were grossly enlarged, although maintaining "normal" hexagonal appearance. With the scanning electron microscope (SEM), these enlarged cells with stretched intercellular bridges were also noted adjacent to the edge of the epithelial ingrowth. It is obvious that the corneal endothelium in this patient had previously been traumatized, and, after cellular redistribution, enlarged
Zavala EY, Binder PS. Epithelial Ingrowth-Reply. Arch Ophthalmol. 1981;99(4):698. doi:10.1001/archopht.1981.03930010697025
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