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April 1981

Handbook of Cryosurgery

Arch Ophthalmol. 1981;99(4):705-706. doi:10.1001/archopht.1981.03930010705039

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This book is an excellent review of the rapidly developing field of cryosurgery. It covers the uses of cryosurgery in human as well as veterinary medicine.

The book begins with a historical review, and a particularly outstanding section deals with the biophysics of cryosurgery, including the cellular, extracellular, and tissue changes at various temperatures. The anatomical changes occurring at various temperatures and several ways of monitoring the depth and extent of the cryolesion are discussed.

A chapter on the immunologic implications of cryosurgery represents perhaps the most interesting development in this field. Several studies have suggested that cryosurgery creates an antigenic stimulus capable of generating a specific immunologic response against autologous antigens of frozen tissue. Further investigation in this area is certainly indicated.

Of particular interest to the ophthalmologist is a chapter by Dr Zacarian on benign and malignant cutaneous lesions and a chapter by Drs Fraunfelder and Chappell on

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