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June 1981

Ocular Toxicity of Topical Antifungal Agents

Author Affiliations

From the Department of Ophthalmology, Harvard Medical School (Dr Foster); the Department of Cornea Research, Eye Research Institute of Retina Foundation (Dr Foster and Ms Moran-Wallace); the Cornea Service, Massachusetts Eye and Ear Infirmary (Dr Foster and Mr Giovanoni), Boston; and the Division of Ophthalmology, Case Western Reserve University Medical School (Dr Lass), Cleveland.

Arch Ophthalmol. 1981;99(6):1081-1084. doi:10.1001/archopht.1981.03930011081019

• We studied, in a rabbit, the ocular toxicity of topical 1% solutions or suspensions of amphotericin B, flucytosine, miconazole nitrate, and ketoconazole. Flucytosine, miconazole, and ketoconazole did not retard the closure of 8.5-mm corneal epithelial defects; amphotericin B greatly retarded the closure of such defects. Amphotericin B produced dramatic pathologic changes in this model; these changes worsened with each day of therapy. Ketoconazole produced modest biomicroscopically and histologically detectable pathologic changes in the regenerating corneal epithelium; flucytosine and miconazole did not produce such changes.

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