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June 1981

S-Antigen Uveitis in Primates: A New Model for Human Disease

Author Affiliations

From the Clinical Branch (Drs Nussenblatt and de Monasterio) and Laboratory for Vision Research (Dr Kuwabara), National Eye Institute, Bethesda, Md; and Department of Ophthalmology, University of Louisville (Dr Wacker).

Arch Ophthalmol. 1981;99(6):1090-1092. doi:10.1001/archopht.1981.03930011090021

• Uveitis was induced in rhesus monkeys immunized with purified retinal Santigen. Focal retinal and subretinal infiltration, in addition to periphlebitic changes, were observed histologically. Immunized monkeys had similar cellmediated in vitro immune responses to the S-antigen as do humans with posterior uveitis. Circulating immune complexes at the time of disease could not be detected. This primate model supports the notion that the S-antigen may play a role in human uveitis.