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July 1981

Absence of Lymphocyte Glucocorticoid Hypersensitivity in Primary Open Angle Glaucoma

Author Affiliations

From the Department of Ophthalmology, Tufts-New England Medical Center (Drs McCarty and Schwartz), and Department of Medicine, Tufts University School of Medicine (Dr Miller), Boston.

Arch Ophthalmol. 1981;99(7):1258-1260. doi:10.1001/archopht.1981.03930020132017

• The glucocorticosteroid sensitivity of patients with primary open angle glucoma and normal patients was determined by the quantity of dexamethasone required to reduce concanavalin A-induced lymphocyte blast transformation to 50% of control values (I50 ). This was performed under culturing conditions employing both serum-free medium and medium supplemented with 10% autologous serum. A comparison of the I50 between normal subjects and those with primary open angle glaucoma did not show a significant difference in steroid sensitivity under either of the two culturing conditions. It is concluded that persons with primary open angle glaucoma do not have a generalized inherited or acquired cellular hypersensitivity to glucocorticoids.

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