Intraocular Lenses Generate Chemotactic Activity in Human Serum: Binkhorst Lecture Part III

Miles A. Galin; Ira M. Goldstein; Audrey Tuberville; H. Daniel Perez; Howard Kaplan

doi:10.1001/archopht.1981.03930020308023

Article

August 1981

Intraocular Lenses Generate Chemotactic Activity in Human Serum: Binkhorst Lecture Part III

Miles A. Galin, MD; Ira M. Goldstein, MD; Audrey Tuberville, MD; et al H. Daniel Perez, MD; Howard Kaplan

Author Affiliations

From the Department of Ophthalmology, New York Medical College (Drs Galin and Tuberville), and the Department of Medicine, New York University Medical Center (Drs Goldstein and Perez and Mr Kaplan). Dr Tuberville is an Implant Fellow of the American Intra-Ocular Implant Society, Santa Monica, Calif.

Arch Ophthalmol. 1981;99(8):1434-1435. doi:10.1001/archopht.1981.03930020308023

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Abstract

• Polymethylmethacrylate lenses with nylon loops activate complement in normal human serum and provoke generation of C5-derived peptides with chemotactic activity for polymorphonuclear leukocytes. These observations may explain one aspect of the pathway of implantinduced inflammation and its clinical consequences.

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Intraocular Lenses Generate Chemotactic Activity in Human Serum: Binkhorst Lecture Part III

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Intraocular Lenses Generate Chemotactic Activity in Human Serum: Binkhorst Lecture Part III

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