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September 1981

Side Effects of Mydriatic-Cycloplegic Solutions-Reply

Author Affiliations


Arch Ophthalmol. 1981;99(9):1654. doi:10.1001/archopht.1981.03930020528031

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In Reply.  —Despite the testimonial of Dr Lindsay, we still warn against extemporaneous mixing of available solutions of phenylephrine and tropicamide. One episode of growth-free cultures does not ensure that the bottles left on the shelf in the office of Dr Lindsay or any other office will remain culture free for the duration of the shelf life. The ability to sterilize containers as well as the sterile environment for mixing the chemicals cannot be as assiduously maintained as required by the pharmaceutical companies.An unfortunate problem is brought to light, however, by Dr Lindsay. Despite the inquiries we have received about when the drug will be commercially manufactured, we have been unsuccessful at convincing a pharmaceutical company to market the drug. The cost of justifying to the Food and Drug Administration the benignity of the medication seems prohibitive.

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