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October 1981

Central Ocular Motor Abnormalities in Duane's Retraction Syndrome

Author Affiliations

From the Neuro-ophthalmology Unit, The Wilmer Ophthalmological Institute (Drs Gourdeau and Miller and Ms Morris), and the Department of Neurology (Dr Zee), The Johns Hopkins Hospital, Baltimore.

Arch Ophthalmol. 1981;99(10):1809-1810. doi:10.1001/archopht.1981.03930020683011

• Duane's retraction syndrome (DRS) is a congenital eye movement disorder characterized by marked limitation or absence of abduction, variable limitation of adduction, and narrowing of the palpebral fissure with retraction of the globe on attempted adduction. We have recently recorded and quantitated ocular motility in five patients with unilateral DRS. In all patients, abduction of the affected eye was greatly limited, whereas adduction was limited to a lesser degree. Abnormalities in saccadic velocities were found in both the affected eye and the sound eye. Results of testing of the vestibulo-ocular reflex, optokinetic nystagmus, and optokinetic afternystagmus showed notable asymmetry. Our results suggest that DRS is produced by a primary brainstem abnormality involving premotor structures.

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