—We read with interest the article by Rynne and Romano.1 Although the authors stated that they had demonstrated the effectiveness of oral steroids in reducing the rebleeding rate in hyphemas, we believe this definitely was not demonstrated adequately by their article. In their article, their so-called control population consisted of patients with hyphemas treated by other physicians in the same institution. There was no random assignment of patients with hyphema to either the control or study group. There was no use of a placebo mentioned in the article.We also noted that an earlier article by Yasuna2 also had a poor control series consisting of patients that he had treated before the use of prednisone. There was no random assignment of study patients to either the control series or the series treated with prednisone.We would like to address the specific criticisms of Rynne and Romano.
Spoor TC, Hammer ME. Traumatic Hyphema-Reply. Arch Ophthalmol. 1981;99(11):2053–2054. doi:10.1001/archopht.1981.03930020931024
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