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December 1981

Thioridazine Levels in the Human Eye

Author Affiliations

From the Departments of Ophthalmology (Drs Kimbrough and Campbell) and Surgical Pathology (Dr Campbell), Mayo Clinic and Mayo Foundation, Rochester, Minn. Dr Kimbrough is now with Quillen-Dishner College of Medicine, Johnson City, Tenn.

Arch Ophthalmol. 1981;99(12):2188-2189. doi:10.1001/archopht.1981.03930021064015

• Thioridazine (Mellaril) hydrochloride was found in human retina and choroid by high-performance liquid chromatography. To our knowledge, this report is the first such study to assess quantitatively the presence of thioridazine in the human eye. Drug uptake occurred in the normal-appearing eye and was higher in the choroid than in the retina. Moreover, uptake occurred while the patient was taking a "safe" dose of thioridazine and when serum levels of thioridazine were within the nontoxic range.