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January 1982

Hydroxychloroquine: Seven-Year Experience

Author Affiliations

From the Department of Ophthalmology (Mr Tobin and Dr Krohel) and the Division of Rheumatology (Dr Rynes), Albany (NY) Medical College, Union University.

Arch Ophthalmol. 1982;100(1):81-83. doi:10.1001/archopht.1982.01030030083006

• Ninety-nine patients were treated with hydroxychloroquine sulfate for connective tissue diseases during a seven-year period. All patients received the medication for at least one year and most were treated with a daily dosage of 400 mg. Four patients experienced toxic effects, but no patient sustained permanent loss of visual acuity. Toxicity did not seem to represent a cumulative dosage effect. Funduscopic and visual field examinations at six-month intervals are sufficient to detect the occasional adverse reactions and prevent serious retinal toxic effects when a maximum daily dosage of 400 mg is maintained.

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