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January 1982

Effect of Sodium Hyaluronate on Corneal Wound Healing

Author Affiliations
From the Department of Ophthalmology, Beth Israel Hospital, Boston.
Arch Ophthalmol. 1982;100(1):152. doi:10.1001/archopht.1982.01030030154018

• With the development of the use of sodium hyaluronate for endothelial cell protection during anterior segment surgery, we were interested in the effect of sodium hyaluronate on corneal wound healing. Therefore, the following experiment was performed. Corneal incisions were made in both eyes of 14 albino rabbits. Sodium hyaluronate was used to fill the anterior chamber of the test eye, and balanced salt solution was used in the control eye. The wounds were sutured with 10-0 nylon. On the seventh postoperative day, wound strength was measured. After suture removal, the intraocular pressure was raised until the wound burst. Results showed no statistical difference between the test and control eye.