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February 1982

Ocular Hypotensive Effects of N-Demethylated Carbachol on Open Angle Glaucoma

Author Affiliations

From the Department of Ophthalmology, National Taiwan University College of Medicine, Taipei (Drs Hung and Hsieh); and the Department of Medical Pharmacology and Toxicology, Texas A & M University College of Medicine, College Station (Dr Chiou).

Arch Ophthalmol. 1982;100(2):262-264. doi:10.1001/archopht.1982.01030030264005

• Ocular hypotensive actions of N-demethylated carbachol hydrochloride (DMC) were studied in patients with open angle glaucoma; 1% pilocarpine hydrochloride solution was used as a reference. Although 1% pilocarpine seemed to be slightly more potent than 6% and 9% DMC solutions, DMC solutions were devoid of the noticeable side effects produced by pilocarpine. In all cases, maximum ocular hypotensive actions were observed six hours after the single-drop medication and were determined as 4.2, 4.6, and 4.8 mm Hg with 6% DMC, 9% DMC, and 1% pilocarpine, respectively.

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