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February 1982

Penetration of Intravenous Moxalactam Into Human Aqueous Humor

Author Affiliations

From the Departments of Microbiology (Dr Uwaydah), Medicine (Dr Uwaydah), and Ophthalmology (Drs Jabbour, Fahd, Jaafar, and Faris), American University of Beirut, Lebanon.

Arch Ophthalmol. 1982;100(2):329-330. doi:10.1001/archopht.1982.01030030331023

• Intraocular penetration of moxalactam disodium, a new broad-spectrum oxa-β-lactam antibiotic, was studied in 18 patients undergoing cataract surgery. The antibiotic was administered in a 2-g single dose by intravenous drip during a 20-minute period. After 40 to 230 minutes, moxalactam aqueous humor concentrations ranged from 1.1 to 5.0 μg/mL (mean, 2.3 μg/mL). The ratio of aqueous humor concentrations to concomitant serum concentrations ranged from 1.6% to 9.8%. The achievable aqueous moxalactam concentrations were well above the minimum inhibitory concentrations of most Gram-negative enteric bacilli but not of Pseudomonas and staphylococci.