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March 1982

Epibulbar IgA Plasmacytoma Occurring in Multiple Myeloma

Author Affiliations

From the Department of Ophthalmology, Louisiana State University (LSU) Medical Center School of Medicine, New Orleans (Dr Franklin); Department of Ophthalmology, Harvard Medical School, the Cornea Service, Massachusetts Eye & Ear Infirmary, and Department of Cornea Research and Morphology Unit, Eye Research Institute of Retina Foundation, Boston (Dr Kenyon); and Department of Ophthalmology (Dr Green) and the Oncology Unit, Department of Medicine (Drs Saral and Humphrey), The Johns Hopkins University School of Medicine, Baltimore.

Arch Ophthalmol. 1982;100(3):451-456. doi:10.1001/archopht.1982.01030030453015

• The ophthalmic manifestations of a 51-year-old man with multiple myeloma included exudative retinal detachments and multiple epibulbar plasmacytomas. The retinal changes resolved with treatment for systemic effects, and the IgAproducing plasmacytomas rapidly resolved with local irradiation. The young age of onset (37 years), the prolonged course (14 years), and the IgA M protein and epibulbar involvement were, collectively, unusual findings in multiple myeloma. The presence of epibulbar, gastrointestinal tract, and prostate involvement suggested a homing mechanism of IgAcommitted cells to mucosal surfaces.