• Thirteen patients with retinitis pigmentosa were graded in terms of vitreous change and compared by vitreous fluorophotometry to an equal number of normal patients. A highly significant difference was found between groups. A high correlation was also noted between severity of vitreous change and midvitreous fluorophotometry values. Certain types of vitreous detachments appear to produce a characteristic "camel hump" in the resultant data. A possible explanation for the increased values is discussed.