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April 1982

Fluorometholone Acetate: A New Ophthalmic Derivative of Fluorometholone

Author Affiliations

From the Departments of Ophthalmology (Drs Kupferman, Berrospi, and Leibowitz) and Pharmacology (Dr Kupferman), Boston University School of Medicine.

Arch Ophthalmol. 1982;100(4):640-641. doi:10.1001/archopht.1982.01030030642023

• Hourly topical administration of 0.1% fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis. This is a significantly greater antiinflammatory effect than we have previously reported for the alcohol derivative of fluorometholone and is not significantly different from the therapeutic effect of 1.0% prednisolone acetate ophthalmic suspension, the most effective corneal anti-inflammatory agent that we have studied to date. Fluorometholone acetate (o.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension.

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