—Dr Sidrys makes an interesting point that emphasizes the value of serendipity.We were engaged in the study of timolol and dichlorphenamide when we did one or two larger grafts to facilitate contact lens fitting. It was then that we noticed that glaucoma seemed not to occur in the patients with larger grafts. At this point, the timolol-dichlorphenamide study was discontinued. As indicated in the article, "the study was discontinued after only 23 patients because of a change in surgical procedure that has made such pressure problems a rarity in our practice."1 It was at this point that we began a separate and independent study of the role of larger donor corneas in preventing the rise in IOP after aphakic keratoplasty.The two studies, therefore, were quite independent, and in the timololdichlorphenamide study, only those patients who had elevated IOPs were considered, so that the absence of
Kaufman HE. Keratoplasty Procedures-Reply. Arch Ophthalmol. 1982;100(4):665. doi:10.1001/archopht.1982.01030030667032
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