• Forty patients with choroidal melanomas received radiation therapy with helium ion-charged particles. Thirty-six of 40 patients either remained stable or demonstrated tumor shrinkage. Seventeen of 18 patients followed up for at least one year after therapy demonstrated tumor regression, with a mean tumor shrinkage of approximately 40%. The most effective method of choroidal melanoma management is unclear. Charged-particle external-beam irradiation may be more applicable and have less ocular morbidity than either radioactive plaques or photocoagulation.
Devron H. Char, Joseph R. Castro, Robert D. Stone, Alexander R. Irvine, Michael Barricks, J. Brooks Crawford, Howard A. Schatz, Lawrence I. Lonn, George F. Hilton, Ariah Schwartz, Jeanne M. Quivey, William Saunders, George T. Y. Chen, John T. Lyman. Helium Ion Therapy for Choroidal Melanoma. Arch Ophthalmol. 1982;100(6):935–938. doi:10.1001/archopht.1982.01030030943008