[Skip to Navigation]
June 1982

Regenerative Effects of Epidermal Growth Factor After Penetrating Keratoplasty in Primates

Author Affiliations

From the Lions Eye Research Laboratories, Louisiana State University Eye Center, New Orleans; and the Delta Regional Primate Research Center, Covington, La. Dr Fabricant is now at the Upland (Calif) Medical Center.

Arch Ophthalmol. 1982;100(6):994-995. doi:10.1001/archopht.1982.01030031002022

• Epidermal growth factor (EGF) was injected into the anterior chambers of 12 rhesus monkeys after the denudation of the central corneal endothelium during autograft transplantation. The animals were treated both at the time of surgery and three weeks after surgery. Clinical appearance and corneal thickness were monitored until the corneas were removed by penetrating keratoplasty ten weeks after the initial treatment. Flat preparations of the corneas showed significantly more endothelial cells in the central corneas of the EGF-treated eyes compared with the control eyes. These findings indicate that EGF is effective in replenishing the corneal endothelium after injury.

Add or change institution