• Five patients with symptomatic giant papillary conjunctivitis were treated with topical cromolyn sodium eyedrops. All patients responded favorably with relief of symptoms. Four of the patients who were subsequently examined while receiving cromolyn therapy had less prominent giant papillae on the upper tarsal conjunctivae. Thus far, the treatment of giant papillary conjunctivitis has been poorly defined and is not always practical. Topical cromolyn eyedrops seem to be helpful in the treatment of this disorder.