• A 75-year-old man had generalized neurofibromatosis (NFT) with bilateral iris nodules and a mature cataract with elevated intraocular pressure in his left eye. At the time of intracapsular cataract extraction, a sector iridectomy was performed. Electron microscopic studies of the iris nodules within the iridectomy specimen unequivocally established that the spindle-shaped cells within the nodules were of melanocytic origin. We believe that the iris nodules in NFT represent melanocytic hamartomas.
Perry HD, Font RL. Iris Nodules in von Recklinghausen's Neurofibromatosis: Electron Microscopic Confirmation of Their Melanocytic Origin. Arch Ophthalmol. 1982;100(10):1635–1640. doi:10.1001/archopht.1982.01030040613012
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