• The penetration of amikacin sulfate into the anterior chamber of the human eye was determined by radioimmunoassay. Bactericidal concentrations of amikacin were not achieved by topical or intravenous administration. Subconjunctival injection did not produce consistent bactericidal concentrations of amikacin in aqueous humor. Poor corneal penetration and subsequent tight binding to iris pigment are responsible for these observations. Tissue or pigment binding is adsorptive, nonspecific, and readily reversible. Amikacin released after being bound retains its bactericidal potency.
Eiferman RA, Stagner JI. Intraocular Penetration of AmikacinIris Binding and Bioavailability. Arch Ophthalmol. 1982;100(11):1817–1819. doi:10.1001/archopht.1982.01030040797018
* * SCHEDULED MAINTENANCE * *
The JAMA Network Sites will be conducting routine maintenance from 10/20/2017 through 10/21/2017. During this window access to content and authentication may be intermittently available. The JAMA Store will be completely unavailable during the maintenance window.