• Fluorescein appearance time (FAT) curves were recorded at 5-s intervals from the feline iris and anterior chamber using a modified video-frame store unit. Anterior chamber washout slopes were also recorded following intracameral injection. The iris FAT interval following intravenous injection was maximally 5 s. Passage of the dye bolus then appeared during the next 10 s, followed by a rapid (100-s) rise to maximum levels. In contrast to the iris, anterior chamber FAT curves recorded from the pupillary space showed an approximate two-minute delay after injection (mean = 1.92 ± 0.360 minutes), followed by a gradual (20-minute) rise to maximum recordable levels. The mean anterior chamber washout rate following intracameral injection of 10-6 g/mL of dye levels was 2.323% ± 0.810%/min. There are potential applications of the method and a need for shorter recording intervals.
O'Rourke J, Joyner R, Lindsay M, Fagan R, Shah R. Fluorescein Appearance Time Curves: Continuous Recordings of Iris and Anterior Chamber Dye Flow Contours. Arch Ophthalmol. 1982;100(11):1825–1827. doi:10.1001/archopht.1982.01030040805020
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