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November 1982

Evaluation of Superoxide Dismutase (Orgotein) in Medical Treatment of Canine Cataract

Author Affiliations

From the Departments of Ophthalmology (Drs Brainard and Petursson) and Pharmacology (Dr Hanna), University of Arkansas for Medical Sciences, Little Rock.

Arch Ophthalmol. 1982;100(11):1832-1834. doi:10.1001/archopht.1982.01030040812022

• Orgotein (Palosein) is a veterinary product with marked superoxide dismutase activity that has been used intracamerally to treat senile cataracts in the dog. Fourteen old dogs with bilateral senile cataracts were injected twice in one eye with orgotein and twice in the other eye with isotonic saline under masked conditions. Observations were made over an average of a 12-week period. No clearing of lenses could be detected and there was no observed subjective improvement in the dogs' visual behavior.