—We agree with Dr Abramson that a two-year follow-up period for treatment of uveal melanoma is too short a time to make any definite statement regarding cure. Indeed, we make that point in our article. However, two years is long enough to learn about many of the complications of treatment. For example, in two reported series on the use of local applicators (cobalt plaques1 and radon gas encapsulated in gold seeds2), most of the enucleations necessitated by continuous tumor enlargement or serious complications were performed within two years of treatment. When data from both series are combined, 11 (37% ) of 30 of the treated eyes were enucleated during the first two years following treatment. Moreover, the frequency of metastatic disease has been reported to rise approximately fourfold during the first year, with the peak death rate occurring in the second year after enucleation.3We cannot accept
Gragoudas ES, Goitein M. Longer Follow-up Periods for Treatment of Uveal Melanoma-Reply. Arch Ophthalmol. 1982;100(11):1855. doi:10.1001/archopht.1982.01030040835031
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