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December 1982

Intraocular Antiviral Penetration

Author Affiliations

From the Department of Ophthalmology, the University of Texas Health Science Center, San Antonio (Dr Poirier); the University of Arizona Medical School, Tucson (Dr Kingham); Wellcome Research Laboratories, Research Triangle Park, NC (Dr de Miranda); and the Hospital Jacaltenango, Jacaltenango, Guatemala (Dr Annel). Dr Kingham is now in private practice in Sarasota, Fla.

Arch Ophthalmol. 1982;100(12):1964-1967. doi:10.1001/archopht.1982.01030040944016

• Aqueous levels of topically applied vidarabine monophosphate, trifluridine, and acyclovir were determined following topical administration in patients with normal corneas prior to cataract extraction. Meager levels in aqueous were found for vidarabine monophosphate, and none for trifluridine. Substantial levels of acyclovir were detected that were well within the therapeutic range of herpes simplex susceptibility.