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—Dr Baker is correct that iophendylate is not a water-soluble material. The nature of the contrast material, however, does not invalidate the clinical syndrome we have described. We did not intend our article to be a statistical evaluation of myelography but only intended to point out this relatively rare occurrence. Our objective is to prevent further investigation of patients who are seen with this unusual, but self-limiting complication of myelography. Speculation as to the cause of this problem is presented only as a speculation.