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January 1983

Blockage of Axonal Transport in Optic Nerve Induced by Elevation of Intraocular Pressure: Effect of Arterial Hypertension Induced by Angiotensin I

Author Affiliations

From the William L. McKnight Vision Research Center, Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine.

Arch Ophthalmol. 1983;101(1):94-97. doi:10.1001/archopht.1983.01040010096017

• Previous studies have shown that elevation of intraocular pressure blocks rapid axonal transport at the lamina cribrosa of the optic nerve. In this study, IOP-induced blockage of axonal transport was greater in cats with elevation of BP induced by angiotensin I than in control animals with normal BP. The fact that cardiovascular factors influenced IOPinduced blockage of axonal transport suggests that it is due to ischemia; if the blockage were a direct mechanical effect of the IOP on the axons, it should be unaffected by BP. The data also suggest that the vasoconstrictive properties of angiotensin I reduced the ability of the vasculature of the optic nerve head to autoregulate when challenged by elevation of IOP.

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