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January 1983

Topical Epinephrine and Regional Ocular Blood Flow in Aphakic Eyes of Rabbits

Author Affiliations

From the Departments of Ophthalmology (Drs Morgan, Mirate, and Green and Ms Bowman) and Physiology (Dr Green), Medical College of Georgia, Augusta.

Arch Ophthalmol. 1983;101(1):112-116. doi:10.1001/archopht.1983.01040010114021

• The effects of 4% topical epinephrine bitartrate on regional ocular blood flow were studied in normal, "sham-operated," and aphakic eyes of rabbits. Anterior uveal blood flow decreased in all cases, but reductions in the ciliary processes were less pronounced in aphakic eyes than in sham-operated eyes. Doubling the dose (from 2 to 4 drops) abolished this difference in the ciliary processes, but the increased dose was accompanied by the emergence of a similar (although lesser) effect in the iris. The latter dose additionally decreased retinal blood flow in aphakic eyes compared with the sham-operated eyes. Lens extraction, thus, seems to remove a notable diffusion barrier to topical epinephrine, resulting in both attenuation of its anterior segment effects and in potentiation of a vasoconstrictive response in the posterior pole.