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January 1983

Ocular Penetration of Amikacin Following Intramuscular Injection

Author Affiliations

From the Departments of Ophthalmology (Drs Wingfield, McDougal, and Roy) and Pharmacology (Dr Hanna), University of Arkansas for Medical Science, Little Rock.

Arch Ophthalmol. 1983;101(1):117-120. doi:10.1001/archopht.1983.01040010119022

• Amikacin sulfate was given intramuscularly (IM) (7.5 mg/kg) to study its ocular penetration in man. Seventy-three patients with cataracts received a single dose and 35 received two doses given 5½ to 12 hours apart. After a single dose the aqueous humor levels of the antibiotic between two and ten hours ranged from 0.15 to 3.10 mg/L (average and median, 1.0 mg/L). Two doses given 5½ to eight hours apart produced an average level of 3.5 mg/L (range, 0.91 to 8.31 mg/L). When the second dose was given nine to 12 hours after the first, the aqueous humor levels were similar to those found for a single dose. Aqueous humor concentrations of 1.0 mg/L of amikacin would be expected to be bactericidal for most gram-negative bacterial pathogens, whereas levels of 3.5 mg/L would inhibit most strains of Staphylococcus aureus and many strains of Pseudomonas aeruginosa.