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February 1983

Botulin Ophthalmoplegia: Clinical and Oculographic Observations

Author Affiliations

From the Neuro-ophthalmology Unit, Departments of Neurological Surgery, Neurology, and Ophthalmology, University of California School of Medicine, San Francisco (Drs Hedges and Hoyt), and the Department of Engineering Science and Physiological Optics, University of California, Berkeley (Drs Jones and Stark). Dr Hedges is a Heed Fellow in Neuro-ophthalmology and is now at the New England Medical Center Hospital, Tufts University, Boston. Dr Jones is a Chancellor's Fellow in Engineering Science at the University of California, Berkeley.

Arch Ophthalmol. 1983;101(2):211-213. doi:10.1001/archopht.1983.01040010213005

• Two patients with botulin ophthalmoplegia had rapid quivering eye motions during attempts to refixate laterally placed objects; these abnormal eye movements occurred in conjunction with a disjunctive limitation of range of eye movements. Oculographic examination showed that the quivering motions were composed of multiple hypometric saccades, many of which had subnormal and stuttering velocities. By blocking acetylcholine release into myoneural junctions, botulin toxin seems to limit the duration of saccadic burst innervation reaching ocular muscle.

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