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March 1983

Presenile Cataracts in Phenytoin-Treated Epileptic Patients

Author Affiliations

From the Department of Ophthalmology (Drs Bar and Savir) and the Experimental Surgery Unit (Dr Feller), Hasharon Hospital, Petah-Tiqva (Israel), and Tel Aviv University Medical School.

Arch Ophthalmol. 1983;101(3):422-425. doi:10.1001/archopht.1983.01040010422016

• Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium. The known side effects of these drugs are serious and varied, and phenytoin is strongly implicated in the etiology of cataracts in human beings. Results of our research study on rats supported our view on the cataractogenic action of phenytoin.