• A prospective study of 45 patients undergoing bone marrow transplantation included full ocular examination and pretransplant and posttransplant conjunctival biopsies. The major finding was the development of a severe keratoconjunctivitis sicca syndrome that developed in 20 of the 45 patients and closely correlated with the occurrence of acute graft-v-host disease (GVHD). An acute pseudomembranous conjunctivitis in the fulminant stage of acute GVHD developed in six patients. A further ten patients made up a retrospective assessment of bone marrow transplantation and confirmed these clinical findings.
Hirst LW, Jabs DA, Tutschka PJ, Green WR, Santos GW. The Eye in Bone Marrow Transplantation: I. Clinical Study. Arch Ophthalmol. 1983;101(4):580–584. doi:10.1001/archopht.1983.01040010580010
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