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April 1983

Quantitation of Tear Lysozyme Levels in Dry-Eye Disorders

Author Affiliations

From the Francis I. Proctor Foundation for Research in Ophthalmology and the Department of Ophthalmology, University of California School of Medicine, San Francisco.

Arch Ophthalmol. 1983;101(4):634-635. doi:10.1001/archopht.1983.01040010634022

• A simple, rapid, reproducible method of quantifying tear lysozyme levels with a dual-channel spectrophotometer was used to compare normal subjects and those with dry-eye syndrome. The method was sensitive (80%) and specific (85%) and had a predictive value of a positive result of 83%. One patient with clinical manifestations of dry-eye syndrome and paradoxically elevated levels of tear lysozyme was found to have underlying sarcoidosis.

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