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June 1983

Intracorneal Lens Implantation

Author Affiliations

From the Cornea Service of the Massachusetts Eye and Ear Infirmary (Drs Sendele, Abelson, and Kenyon); the Morphology Unit (Drs Sendele and Kenyon and Ms Hanninen), and the Ocular Allergy Laboratory (Dr Abelson), Eye Research Institute of Retina Foundation; and the Department of Ophthalmology, Harvard Medical School (Drs Sendele, Kenyon, and Abelson), Boston. Presented at the semiannual symposium of the Keratorefractive Society, New Orleans, May 23, 1981.

Arch Ophthalmol. 1983;101(6):940-944. doi:10.1001/archopht.1983.01040010940018

• In previous experiments, we found that a high-water-content hydroxyethyl methacrylate (Permalens) hydrogel implant was not only well tolerated within the rabbit corneal stroma but also would successfully alter the anterior radius of curvature, and thus the refractive state, of the rabbit eye. The same lens material implanted in the cornea of a patient with aphakic bullous keratopathy was tolerated for six months and decreased epithelial edema but did not alter the refractive state. This cornea, containing the intrastromal lens, was obtained at subsequent penetrating keratoplasty and studied by light and transmission electron microscopy. Morphologically, the epithelium and anterior stroma were not edematous, whereas the stroma posterior to the lens remained edematous. Minimal fibroblastic activity was evident at the lens-stroma interface. There were no signs of inflammation, ulceration, or neovascularization.

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