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June 1983

Antibacterial Effect of Cyanoacrylate Glue

Author Affiliations

From the Department of Ophthalmology, University of Louisville and Veterans Administration Medical Center (Dr Eiferman), and the Department of Microbiology, Norton and Kosair-Children's hospitals, Louisville (Dr Snyder).

Arch Ophthalmol. 1983;101(6):958-960. doi:10.1001/archopht.1983.01040010958022

• Enbucrilate (butyl-2-cyanoacrylate; Histoacryl [West Germany], no comparable US product) is a tissue adhesive used in the management of corneal perforations that may have a therapeutic value in suppressing selective pathogens isolated, from corneal infections. In three patients with confirmed corneal infections, varying degrees of inhibition were observed. Bacteriostatic activity was most pronounced against gram-positive microorganisms, and no activity was observed against gram-negative organisms. It appears that this chemical adhesive provided an ancillary means of promoting healing of corneal perforations.

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