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July 1983

Ocular Manifestations of Graft-v-Host Disease

Author Affiliations

From the Fred Hutchinson Cancer Research Center, Seattle.

Arch Ophthalmol. 1983;101(7):1080-1084. doi:10.1001/archopht.1983.01040020082014

• Graft-v-host disease is the major complication of bone marrow transplantation for the leukemias and aplastic anemia. In the clinical evaluation of eye problems of patients with acute graft-v-host disease, findings reveal a disease process of keratoconjunctivitis that appears to represent a specific pathologic eye syndrome in which the conjunctivae and occasionally the cornea represent an immunologic target of graft-v-host disease. Additional studies of eye problems of chronic graft-v-host disease reveal the persistent nature of keratitis sicca and the morbid sequelae of the immunoincompetent patient.

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