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July 1983

Aqueous-Humor Concentrations of Amikacin-Reply

Arch Ophthalmol. 1983;101(7):1145-1146. doi:10.1001/archopht.1983.01040020147030

In Reply.  —Antibiotics given by the parenteral route, as a rule, yield low levels of the drug in the aqueous humor of the normal human eye. When an antibiotic is found that produces bacterial inhibitory levels in the aqueous humor following parenteral use, that agent can be recommended as an adjunct to topical and subconjunctival antibiotics for treatment of infections in the anterior chamber. Therefore, it is of interest that 7.5 mg/kg of amikacin given intramuscularly produced an average amikacin concentration of 1 mg/L in the aqueous humor two to ten hours later. When this initial dose was followed 5½ to eight hours later by a second injection, the average accumulated level was 3.5 mg/L. Recently, Eiferman and Stagner1 were unable to detect amikacin in the aqueous humor when given IV one half hour prior to cataract extraction. Perhaps the samples were taken too early; however, there is no