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September 1983

Intravitreous Silicone Injection: Histopathologic Findings in a Human Eye After 12 Years

Author Affiliations

From the Eye Research Institute of Retina Foundation (Drs Ni, Wang, and Schepens); the Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School (Drs Albert and Ni), Boston; and the Eye, Ear, Nose, and Throat Hospital, Shanghai First Medical College (Drs Ni and Wang).

Arch Ophthalmol. 1983;101(9):1399-1401. doi:10.1001/archopht.1983.01040020401013

• Histopathologic changes occurred in a human eyeball enucleated 12 years after intravitreous silicone injection for the treatment of complicated retinal detachment with massive preretinal membrane. Silicone "bubbles" (droplets) were found in the chamber angle, iris, ciliary body, retina, and preretinal and subretinal membrane, as well as in the optic nerve. Clinically, glaucoma developed in the eye. A review of the literature indicates that the common late complications of intravitreous silicone injection are cataract, glaucoma, and retinal changes.