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September 1983

Ocular Tissue Absorption of Minocycline in the Rabbit

Author Affiliations

From the Francis I. Proctor Foundation for Research in Ophthalmology, Department of Ophthalmology, University of California, San Francisco. Dr Ghosheh is a Cecilia Vaughan fellow.

Arch Ophthalmol. 1983;101(9):1426-1428. doi:10.1001/archopht.1983.01040020428020

• After intramuscular (IM) administration of minocycline hydrochloride, concentrations of the drug that would be adequate for the control of sensitive organisms (>0.5 μg/g of tissue) were detectable in the cornea, iris, and retinochoroid 3, 6, and 12 hours after a single injection. The concentration of the drug in the aqueous humor was greater than in the vitreous humor. Following a single IM injection of 40 mg/kg, the drug level was found to be significantly higher in the iris and aqueous humor of pigmented rabbits than in the corresponding tissues of albino rabbits. The drug seems to concentrate in the pigmented layers of the ocular tissue.

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