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October 1983

Orbital Leiomyosarcoma After Radiation Therapy for Bilateral Retinoblastoma

Author Affiliations

From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC (Drs Folberg and Zimmerman; The Lankenau and Wills Eye Hospitals, Philadelphia (Dr Flanagan); and the Pacific Medical Center, San Francisco (Drs Cleasby and Spencer).

Arch Ophthalmol. 1983;101(10):1562-1565. doi:10.1001/archopht.1983.01040020564012

• Leiomyosarcoma rarely occurs in the orbit and is seldom encountered as a postirradiation sarcoma in any anatomic location. Three patients with bilateral retinoblastoma who had received radiation therapy are known to have orbital leiomyosarcoma develop in their third decade of life. The clinical and pathological data pertaining to two of these patients are given and discussed herein.

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