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December 1983

Intensive Plasmapheresis in the Treatment of Diabetic Retinopathy

Author Affiliations

From the Department of Medicine, Stanford (Calif) University School of Medicine (Drs Wall, Myers, Basso, Rubenstein, and Schrier), and the Zweng Memorial Retinal Research Foundation, Menlo Park, Calif (Dr Little and Ms Casten).

Arch Ophthalmol. 1983;101(12):1889-1893. doi:10.1001/archopht.1983.01040020891011

• Two insulin-dependent diabetic patients with advanced nonproliferative and early proliferative retinopathy showed regression of diabetic retinopathy after three weeks of intensive plasmapheresis. Because of the sudden unexplained death in one patient, the study was stopped. However, these observations in this pilot study suggest that factors mediated through plasma contribute to the pathogenesis of diabetic microangiopathy.